[99mTc-OCTREOTIDE in patients with neuroendocrine tumors from the GI tract]. / 99mTc-OCTREOTIDE en pacientes con tumores neuroendócrinos gastroenteropancreáticos.
Acta Gastroenterol Latinoam
; 40(4): 332-8, 2010 Dec.
Article
em Es
| MEDLINE
| ID: mdl-21381408
ABSTRACT
INTRODUCTION:
It has been demonstrated that scintigraphy with somatostatin analogues is useful for the diagnosis, staging and follow up of patients with neuroendocrine tumors from the gastrointestinal tract (NET-GIT). Some studies suggest that the use of 99mTc-Hydrazinonicotinyl-Tyr3-octreotide (99mTc-HYNIC-TOC) yields similar diagnostic results than the use of 111In-DTPA-octreotide.OBJECTIVE:
To determine the clinical value of scintigraphy using 99mTc-HYNIC-TOC for the detection of primary and secondary lesions in patients with NET-GIT.METHODS:
From September 2004 to May 2009, 32 patients (17 women, age range 18 to 82 years old) with histologically proven or clinically suspected NET-GIT underwent scintigraphy using 99mTc-HYNIC-TOC Patients underwent a whole body scan, with additional static images of abdomen and pelvis, followed by SPECT at 4-hrs post injection of 925 MBq of the tracer. Patients underwent clinical, imaging and histopathology follow-up during 3 to 18 months.RESULTS:
Histopathology demonstrated carcinoid tumor in 20 patients, insulinoma in 2, gastrinoma in 2 and non-specific NET-GIT in 6. Total sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 87%, 100%, 100%, 89% and 94%, respectively. To detect the primary lesion, the values were 94%, 100% 100%, 94% and 97%, respectively and to detect secondary lesions, 79%, 100%, 100%, 86% and 91%, respectively.CONCLUSIONS:
99mTc-HYNIC-TOC is a specific somatostatin analog, with high affinity to receptor subtype SST-2, widely available and affordable by Latin American countries. It has a good performance to be used for diagnosis, staging and follow-up of patients with NET-GIT.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Octreotida
/
Compostos de Organotecnécio
/
Tumores Neuroendócrinos
/
Compostos Radiofarmacêuticos
/
Neoplasias Gastrointestinais
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
Es
Revista:
Acta Gastroenterol Latinoam
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Uruguai
País de publicação:
AR
/
ARGENTINA