[Immunological effects of captopril and ramipril in patients with hypertension]. / Immunologicheskii éffekt kaptoprila i ramiprila u bol'nykh gipertonicheskoi bolezn'iu.
Klin Med (Mosk)
; 68(2): 61-4, 1990 Feb.
Article
em Ru
| MEDLINE
| ID: mdl-2139910
ABSTRACT
Fifteen patients with essential hypertension underwent treatment with captopril (7 patients) and ramipril (8 patients). The drugs belong to angiotensin-converting enzyme (ACE) inhibitors. Pretreatment immunological examination and that after a 10-15-week course of the above therapy involved measurements of IgG, IgA, IgE and beta 2-microglobulin. The analysis of the trend in the immunological indices demonstrated that captopril, distinct from ramipril by the presence of a sulfhydryl group, caused a decrease in immunological parameters suggesting a potential role of culfhydryl groups in mediating ACE inhibitor action on the immune system. The immunological properties of captopril may appear useful in various systemic diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Bicíclicos com Pontes
/
Hidrocarbonetos Aromáticos com Pontes
/
Imunoglobulinas
/
Captopril
/
Hipertensão
Limite:
Adult
/
Humans
/
Male
Idioma:
Ru
Revista:
Klin Med (Mosk)
Ano de publicação:
1990
Tipo de documento:
Article