Transporter-mediated drug-drug interactions.
Clin Pharmacol Ther
; 89(4): 481-4, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21423238
ABSTRACT
Transporters are membrane-bound proteins that control the access of endogenous and xenobiotics (drugs) to various sites in the human body. They influence drug pharmacokinetics and pharmacodynamics (both benefit and risk) by affecting a drug's absorption, distribution, metabolism (via control of access to metabolizing enzymes), and excretion (ADME) and by controlling drug concentrations at the site of action. Like metabolizing enzymes, transporters have binding sites that are saturable and can be inhibited or induced.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Xenobióticos
/
Interações Medicamentosas
Limite:
Humans
Idioma:
En
Revista:
Clin Pharmacol Ther
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos