The effect of target-controlled infusion of low-dose ketamine on heat pain and temporal summation threshold.
J Anesth
; 25(4): 516-22, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21512823
ABSTRACT
PURPOSE:
We investigated the heat pain threshold (HPT) and temporal summation threshold (TST) before and after target-controlled infusion (TCI) of ketamine with an effect-site concentration (Ce) of 30 and 60 ng/ml.METHODS:
Healthy young volunteers (n = 20) were enrolled. A thermode was applied to the volar side of each volunteer's right forearm, and HPT and TST were measured before and after TCI of ketamine. Vital signs and psychedelic effects according to ketamine infusion were also observed before and after TCI of ketamine.RESULTS:
Mean HPT after TCI of ketamine with a Ce of 30 and 60 ng/ml did not increase significantly. However, mean TST after TCI of ketamine with a Ce of 30 and 60 ng/ml increased significantly, in a dose-dependent fashion, compared with the value before ketamine TCI. Vital signs showed no significant difference before and after ketamine TCI. The visual analog scale score of psychedelic symptoms was higher with a Ce of 60 ng/ml than with 30 ng/ml.CONCLUSIONS:
TCI of ketamine with a Ce of 30 and 60 ng/ml increased TST but not HPT.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Medição da Dor
/
Limiar da Dor
/
Somação de Potenciais Pós-Sinápticos
/
Ketamina
/
Anestésicos Dissociativos
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Anesth
Assunto da revista:
ANESTESIOLOGIA
Ano de publicação:
2011
Tipo de documento:
Article