Soluble and membrane-associated interleukin 2 receptor-alpha expression in rhesus monkeys infected with simian immunodeficiency virus.
Lab Invest
; 62(4): 435-43, 1990 Apr.
Article
em En
| MEDLINE
| ID: mdl-2159083
ABSTRACT
More than 80% of rhesus monkeys infected with simian immunodeficiency virus (SIV) were found to have elevated levels of soluble interleukin-2 receptor (IL-2R) in their serum during the course of infection. All long-term survivors had stably elevated levels of soluble IL-2R. The highest levels of soluble IL-2R correlated with the expression of IL-2R on tissue macrophages. Although IL-2R expression was induced on alveolar macrophages by infection with SIV in vitro, expression of IL-2R on tissue macrophages in vivo was not associated with concurrent SIV protein expression in the same cells. Moreover, in animals with high soluble IL-2R levels, there was an inverse relationship between the numbers of cells expressing IL-2R and cells expressing viral protein. The results suggest that the induction of IL-2R may be an indirect or secondary effect of SIV infection. Changes in expression of macrophage-elaborated factors, such as that of IL-2R described in this report, may play a crucial role in some of the pathologic features of acquired immunodeficiency syndrome.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Interleucina-2
/
Infecções por Retroviridae
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Lab Invest
Ano de publicação:
1990
Tipo de documento:
Article