Interactions between dietary fat intake and FASN genetic variation influence LDL peak particle diameter.
J Nutrigenet Nutrigenomics
; 4(3): 137-45, 2011.
Article
em En
| MEDLINE
| ID: mdl-21646813
ABSTRACT
BACKGROUND:
The small, dense LDL phenotype is associated with an increased cardiovascular disease risk. A genome-wide scan performed on the Quebec Family Study (QFS) revealed a quantitative trait locus for LDL peak particle diameter (LDL-PPD) on the 17q21 region. A positional candidate gene - the fatty acid synthase gene (FASN) - encodes a key enzyme in the biogenesis of membrane lipids. FASN may play a role in the regulation of feeding and may be a potential therapeutic target for obesity and insulin resistance.METHODS:
Analyses were performed on 592 subjects of the QFS. Dietary fat was estimated by a 3-day food record. LDL-PPD was measured by gradient gel electrophoresis on polyacrylamide gradient gels.RESULTS:
Five single nucleotide polymorphisms were genotyped in FASN gene. FASN rs4246444 was associated with LDL-PPD, but only when fat intake was taken into account (p = 0.001). High and low lipid consumers were defined using a cutoff of 35% of dietary fat intake. Carriers of the variant allele showed smaller LDL-PPD only when consuming a high amount of fat. This association remained significant after adjustments for age, sex, body mass index and plasma triglyceride levels.CONCLUSION:
The results suggest that dietary fat intake may modify the effect of the FASN rs4246444 polymorphism on LDL-PPD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Gorduras na Dieta
/
Ácido Graxo Sintase Tipo I
/
Lipoproteínas LDL
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Nutrigenet Nutrigenomics
Assunto da revista:
CIENCIAS DA NUTRICAO
/
GENETICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Canadá