[New perspectives for radiosensitization in pancreatic carcinoma: a review of mechanisms involved in pancreatic tumorigenesis]. / Mécanismes de carcinogenèse des cancers du pancréas : quelles pistes pour la radiosensibilisation ?
Cancer Radiother
; 15(5): 365-75, 2011 Aug.
Article
em Fr
| MEDLINE
| ID: mdl-21664851
ABSTRACT
Pancreatic carcinoma is the fifth leading cause of cancer-related mortality. The 5-year overall survival is less than 5 %. This very poor prognosis can be explained both by late diagnosis and by treatment resistance, including resistance to radiation therapy. A better understanding of the pancreatic tumorigenesis and knowledge of the most frequent mutations in pancreatic adenocarcinoma (KRAS, p16, TP53, Smad4) open new perspectives for the development of more effective treatments. This review presents the major genetic and molecular alterations in pancreatic cancer that could be targeted to improve radiosensitization.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Transformação Celular Neoplásica
/
Carcinoma Ductal Pancreático
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Idioma:
Fr
Revista:
Cancer Radiother
Assunto da revista:
NEOPLASIAS
/
RADIOTERAPIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
França