Diffusive searches in high-dimensional spaces and apparent 'two-state' behaviour in protein folding.
J Phys Condens Matter
; 18(6): 1861-8, 2006 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-21697560
ABSTRACT
We extend a simple model for protein folding as a high-dimensional diffusive search. By solving a steady-state diffusion equation on a hypersphere centred on an absorbing 'native state' we find the general property that the kinetics of such a search will always be nearly single exponential. This explains the common observation of such simple 'two-state' folding kinetics in models that contain considerable intermediate structure. It also suggests that the experimental signature of single-exponential folding kinetics does not imply a simple two-state structure to the folding space.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Phys Condens Matter
Assunto da revista:
BIOFISICA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Reino Unido