Highlighting chromosome loops in DNA-picked chromatin (DPC).
Epigenetics
; 6(8): 979-86, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21725198
ABSTRACT
Growing evidence supports the concept that dynamic intra- and inter-chromosomal links between specific loci contribute to the creation of cell-type specific gene expression profiles. Therefore, analysis of the establishment of peculiar functional correlations between sites, also distant on linear DNA, that govern the transcriptional process appears to be of fundamental relevance. We propose here an experimental approach showing that 17ß-estradiol-induced transcription associates to formation of loops between the promoter and termination regions of hormone-responsive genes. This strategy reveals as a tool to be also suitably used, in conjunction with automated techniques, for an extensive analysis of sites shared by multiple genes for induced expression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Cromatina
/
Cromossomos Humanos
/
Elementos de Resposta
/
Proteômica
/
Estradiol
/
Conformação de Ácido Nucleico
Limite:
Female
/
Humans
Idioma:
En
Revista:
Epigenetics
Assunto da revista:
GENETICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Itália