Bromopyridazinedione-mediated protein and peptide bioconjugation.
Chem Commun (Camb)
; 47(31): 8781-3, 2011 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-21738916
ABSTRACT
Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is described. The conjugates are cleavable in an excess of thiol, including cytoplasmically-relevant concentrations of glutathione, and show a high level of hydrolytic stability. The constructs have the potential for four points of chemical attachment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Piridazinas
/
Proteínas
Idioma:
En
Revista:
Chem Commun (Camb)
Assunto da revista:
QUIMICA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido