Functional neuroimaging studies in normal aging.

ABSTRACT

With an expanding aging population, it is increasingly important to gain a better understanding of the changes in cognition and neural integrity that occur in normal aging. The advent of non-invasive functional neuroimaging techniques has spurred researchers to examine cognition and neural functioning in healthy older adults. A significant amount of research has been produced since this time and has led to influential theories of aging such as the hemispheric asymmetry reduction for older adults (HAROLD) model and the compensatory recruitment hypothesis. This chapter discusses advances in our understanding of normal aging achieved through the use of functional neuroimaging. Research examining age-related changes in domains such as attention, memory, and executive functioning, as well as imaging of the resting-state and the influences of genetic risk factors (e.g., APOE genotype), are discussed. In conclusion, limitations of the current literature and important avenues for future research are proposed.