Your browser doesn't support javascript.
loading
Fibroblast growth factor-2 deficiency causes defects in adult hippocampal neurogenesis, which are not rescued by exogenous fibroblast growth factor-2.
Werner, Sandra; Unsicker, Klaus; von Bohlen und Halbach, Oliver.
Afiliação
  • Werner S; Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, Heidelberg, Germany. sandra.werner@anat.uni-freiburg.de
J Neurosci Res ; 89(10): 1605-17, 2011 Oct.
Article em En | MEDLINE | ID: mdl-21800348
Neurogenesis within the adult brain is restricted to selected areas, one of which is the dentate gyrus (DG). Several growth factors have been reported to affect neurogenesis in the adult DG. However, a role of fibroblast growth factor-2 (FGF-2) in adult hippocampal neurogenesis has not been firmly established. We have analyzed neurogenesis in the DG using in vivo and in vitro approaches. FGF-2(-/-) mice revealed no alterations in the number of proliferating cells but a significant decrease in the numbers of newly generated neurons. Moreover, FGF-2 added to hippocampal slice cultures from FGF-2(-/-) mice was unable to rescue the phenotype. Although an increase in death of neurogenic cells in the FGF-2-deficient DG could not be specifically demonstrated, there was a massive increase in global cell death in FGF-2(-/-) hippocampal slice cultures compared with slices from wild-type mice. Cell death could not be prevented by addition of FGF-2. Neutralization of endogenous FGF-2 in hippocampal slices did not interfere with neurogenesis in a short-term paradigm. Together, our data suggest that FGF-2 is essentially required for maturation of new neurons in adult hippocampal neurogenesis but is likely to operate synergistically in combination with other mechanisms/growth factors.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator 2 de Crescimento de Fibroblastos / Giro Denteado / Neurogênese / Plasticidade Neuronal Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: J Neurosci Res Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator 2 de Crescimento de Fibroblastos / Giro Denteado / Neurogênese / Plasticidade Neuronal Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: J Neurosci Res Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos