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Evaluation of crosslinked and non-crosslinked biologic prostheses for abdominal hernia repair.
de Castro Brás, L E; Shurey, S; Sibbons, P D.
Afiliação
  • de Castro Brás LE; Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow HA1 1UJ, UK. lisandrabras@gmail.com
Hernia ; 16(1): 77-89, 2012 Feb.
Article em En | MEDLINE | ID: mdl-21805341
INTRODUCTION: Abdominal wall defects and incisional hernias represent a challenging problem. Currently, several commercially available biologic prostheses are used clinically for hernia repair. We compared the performance and efficacy of two non-crosslinked meshes in ventral hernia repair to two crosslinked prostheses in a rodent model. METHODS: Animals were divided into 12 groups (4 matrix types and 3 termination time-points per matrix). A ventral defect was carefully created and overlapped with the biologic prosthesis. RESULTS: Major complications were seroma induction (3 mesh types), implant extrusion (1 mesh type), severe inflammatory and immune responses (non-crosslinked mesh), fibrosis and mineralisation (3 mesh types). After inflammation resolution, 3 of the matrices tested supported hernia healing but with marked tissue and temporal differences. AlloDerm(®*) and Surgisis Gold™ showed tissue reactivity with the host and a rapid rate of matrix remodelling. Bard CollaMend™(*) Implant proved to be inept for hernia repair under the conditions tested. Permacol™ biological implant integration with host tissue increased over time, supporting hernia healing with strength of tissue, and appears to be a safe prosthetic material for ventral hernia repair based on the results of this rodent study.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Telas Cirúrgicas / Materiais Biocompatíveis / Parede Abdominal / Hérnia Ventral Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Hernia Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2012 Tipo de documento: Article País de publicação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Telas Cirúrgicas / Materiais Biocompatíveis / Parede Abdominal / Hérnia Ventral Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Hernia Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2012 Tipo de documento: Article País de publicação: França