Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice.
Fitoterapia
; 82(7): 1128-32, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21807074
ABSTRACT
We investigated the effect of Z-ligustilide (LIG) on scopolamine-induced memory impairment in ICR mice. LIG (2.5-40 mg/kg) or tacrine (10 mg/kg) was orally administrated for 26 days. Behavior was examined in the Morris water maze and Y-maze after scopolamine administration (2 mg/kg, i.p.). The central acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) activities were assessed spectrophotometrically. LIG significantly improved spatial long-term memory and short-term memory impairment, inhibited AChE activity and increased ChAT activity. Moreover, LIG and tacrine showed the comparable efficacy in both neurobehavioral and cholinergic evaluation. These data suggest that LIG may alleviate memory deficits probably via enhancing cholinergic function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
4-Butirolactona
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Extratos Vegetais
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Colinérgicos
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Angelica
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Fitoterapia
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Memória
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Transtornos da Memória
Limite:
Animals
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China