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No evidence that extended tracts of homozygosity are associated with Alzheimer's disease.
Sims, Rebecca; Dwyer, Sarah; Harold, Denise; Gerrish, Amy; Hollingworth, Paul; Chapman, Jade; Jones, Nicola; Abraham, Richard; Ivanov, Dobril; Pahwa, Jaspreet Singh; Moskvina, Valentina; Dowzell, Kimberley; Thomas, Charlene; Stretton, Alexandra; Lovestone, Simon; Powell, John; Proitsi, Petroula; Lupton, Michelle K; Brayne, Carol; Rubinsztein, David C; Gill, Michael; Lawlor, Brian; Lynch, Aoibhinn; Morgan, Kevin; Brown, Kristelle S; Passmore, Peter A; Craig, David; McGuiness, Bernadette; Todd, Stephen; Johnston, Janet A; Holmes, Clive; Mann, David; Smith, A David; Love, Seth; Kehoe, Patrick G; Hardy, John; Mead, Simon; Fox, Nick; Rossor, Martin; Collinge, John; Livingston, Gill; Bass, Nicholas J; Gurling, Hugh; McQuillin, Andrew; Jones, Lesley; Holmans, Peter A; O'Donovan, Michael; Owen, Michael J; Williams, Julie.
Afiliação
  • Sims R; MRC Centre for Neuropyschiatric Genetics and Genomics, Department of Psychological Medicine and Neurology, Cardiff University, Heath Park. simsrc@cardiff.ac.uk
Am J Med Genet B Neuropsychiatr Genet ; 156B(7): 764-71, 2011 Dec.
Article em En | MEDLINE | ID: mdl-21812096
ABSTRACT
We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Doença de Alzheimer / Homozigoto Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Am J Med Genet B Neuropsychiatr Genet Assunto da revista: GENETICA MEDICA / NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2011 Tipo de documento: Article País de publicação: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Doença de Alzheimer / Homozigoto Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Am J Med Genet B Neuropsychiatr Genet Assunto da revista: GENETICA MEDICA / NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2011 Tipo de documento: Article País de publicação: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA