Sporadic amyotrophic lateral sclerosis: new hypothesis regarding its etiology and pathogenesis suggests that astrocytes might be the primary target hosting a still unknown external agent.
Arq Neuropsiquiatr
; 69(4): 699-706, 2011 Aug.
Article
em En
| MEDLINE
| ID: mdl-21877044
ABSTRACT
This article briefly describes the already known clinical features and pathogenic mechanisms underlying sporadic amyotrophic lateral sclerosis, namely excitoxicity, oxidative stress, protein damage, inflammation, genetic abnormalities and neuronal death. Thereafter, it puts forward the hypothesis that astrocytes may be the cells which serve as targets for the harmful action of a still unknown environmental agent, while neuronal death may be a secondary event following the initial insult to glial cells. The article also suggests that an emergent virus or a misfolded infectious protein might be potential candidates to accomplish this task.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Astrócitos
/
Estresse Oxidativo
/
Esclerose Lateral Amiotrófica
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Arq Neuropsiquiatr
Ano de publicação:
2011
Tipo de documento:
Article