Neuronal structural protein polymorphism and concussion in college athletes.
Brain Inj
; 25(11): 1108-13, 2011.
Article
em En
| MEDLINE
| ID: mdl-21902461
ABSTRACT
OBJECTIVE:
To examine the association between a neuronal structural protein polymorphism and the frequency and severity of concussions in college athletes.METHODS:
Forty-eight athletes with previous self-reported history of a concussion were matched with 48 controls that did not report a history of concussion. Each group was genotyped for neurofilament heavy (NEFH) polymorphism rs#165602 in this retrospective case-control study.RESULTS:
There was no significant association (χ(2 )= 0.487, p = 0.485) between carrying the NEFH rare allele and a history of one or more concussions due to small effect sizes. A Fisher's exact test revealed no significant association (p = 1.00, Ï = -0.03) between the presence of NEFH rare allele and a history of multiple concussions. The independent t-tests revealed no significant differences in duration of signs and symptoms (t = 1.41, p = 0.17, d = 0.48) or return to play (t = 0.23, p = 0.82, d = 0.08) between NEFH rare allele carrier and non-carriers.CONCLUSIONS:
Among college athletes, carrying the rare allele assessed may not influence an athlete's susceptibility to sustaining a concussion or return to play duration following a concussion.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estudantes
/
Concussão Encefálica
/
Polimorfismo de Nucleotídeo Único
/
Atletas
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Brain Inj
Assunto da revista:
CEREBRO
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos