[Patterns of the histone modifications across the chicken alpha-globin genes domain].
Mol Biol (Mosk)
; 45(4): 662-7, 2011.
Article
em Ru
| MEDLINE
| ID: mdl-21954598
ABSTRACT
Using native chromatin immunoprecipitation (N-ChIP) followed by TaqMan RT-PCR quantitative analysis we have determined the profiles of histone acetylation and histone methylation within the alpha-globin gene domain before and after switching of embryonic globin genes expression. The results obtained do not support a supposition that the inactivation of the embryonic alpha-type globin gene pi in erythroid cells of the adult lineage is mediated via formation of an inactive chromatin domain. On the other hand we have demonstrated that suppression of the gene pi activity in erythroid cells of adult lineage correlates with the decrease of the histone acetylation level within the embryonic subdomain of the alpha-globin gene domain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Histonas
/
Alfa-Globinas
Limite:
Animals
Idioma:
Ru
Revista:
Mol Biol (Mosk)
Ano de publicação:
2011
Tipo de documento:
Article