mRNA 3' end processing and more--multiple functions of mammalian cleavage factor I-68.
Wiley Interdiscip Rev RNA
; 2(1): 79-91, 2011.
Article
em En
| MEDLINE
| ID: mdl-21956970
ABSTRACT
The formation of defined 3(') ends is an important step in the biogenesis of mRNAs. In eukaryotic cells, all mRNA 3(') ends are generated by endonucleolytic cleavage of primary transcripts in reactions that are essentially posttranscriptional. Nevertheless, 3(') end formation is tightly connected to transcription in vivo, and a link with mRNA export to the cytoplasm has been postulated. Here, we briefly review the current knowledge about the two types of mRNA 3(') end processing reactions, cleavage/polyadenylation and histone RNA processing. We then focus on factors shared between these two reactions. In particular, we discuss evidence for new functions of the mammalian cleavage factor I subunit CF I(m) 68 in histone RNA 3(') processing and in the export of mature mRNAs from the nucleus to the cytoplasm.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Processamento de Terminações 3' de RNA
/
Fatores de Poliadenilação e Clivagem de mRNA
/
Mamíferos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Wiley Interdiscip Rev RNA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Suíça