Long-standing prion dementia manifesting as posterior cortical atrophy.
Alzheimer Dis Assoc Disord
; 26(3): 289-92, 2012.
Article
em En
| MEDLINE
| ID: mdl-21959360
ABSTRACT
Prion diseases commonly manifest with the phenotype of subacute myoclonic encephalopathy. However, genetic forms of prion disease may have prolonged evolution mimicking neurodegenerative disease. We present the clinical and neuropathological features of a family with an early and long-standing dementia manifesting with posterior cortical atrophy and related to a 120 bp insertional mutation of the prion protein gene. Two cases exhibited mixed prion and Aß pathology. The differential diagnosis with Alzheimer disease is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Príons
/
Córtex Cerebral
/
Doenças Priônicas
/
Demência
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Alzheimer Dis Assoc Disord
Assunto da revista:
NEUROLOGIA
/
PSIQUIATRIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
França