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Oxidant-antioxidant imbalance in horses infected with equine infectious anaemia virus.
Bolfa, Pompei Florin; Leroux, Caroline; Pintea, Adela; Andrei, Sanda; Catoi, Cornel; Taulescu, Marian; Tabaran, Flaviu; Spînu, Marina.
Afiliação
  • Bolfa PF; Department of Pathology, Faculty of Veterinary Medicine, USAMV, Calea Manastur 3-5, Cluj-Napoca 400372, Romania. pompeibolfa@gmail.com
Vet J ; 192(3): 449-54, 2012 Jun.
Article em En | MEDLINE | ID: mdl-21962828
This study assesses the impact of equine infectious anaemia virus (EIAV) infection on the oxidant/antioxidant equilibrium of horses. Blood samples from 96 Romanian horses aged 1-25 years, were divided into different groups according to their EIAV-infection status, age, and time post-seroconversion. The effect of infection on oxidative stress was estimated by measuring enzymatic antioxidants (superoxide dismutase [SOD], glutathione peroxidase [GPx] and catalase), non-enzymatic antioxidants (uric acid and carotenoids), and lipid peroxidation (malondialdehyde [MDA]). Infection modified the oxidant/antioxidant equilibrium in the horses, influencing GPx and uric acid levels (P<0.05). Time post-seroconversion also contributed to oxidative stress imbalance, exhibiting a significant influence on both SOD and MDA concentrations in the blood (P<0.05). Animal age did not have a significant influence on oxidative stress. Recently infected horses (<1 year following seroconversion), and horses >5 years old, represented the most vulnerable category in terms of oxidative stress, followed by recently infected animals <5 years old. The results of this study are novel in implicating EIAV infection in the development of oxidative stress in horses.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anemia Infecciosa Equina / Oxidantes / Vírus da Anemia Infecciosa Equina / Antioxidantes Limite: Animals Idioma: En Revista: Vet J Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Romênia País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anemia Infecciosa Equina / Oxidantes / Vírus da Anemia Infecciosa Equina / Antioxidantes Limite: Animals Idioma: En Revista: Vet J Assunto da revista: MEDICINA VETERINARIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Romênia País de publicação: Reino Unido