The impact of aging on memory T cell phenotype and function in the human bone marrow.
J Leukoc Biol
; 91(2): 197-205, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22013229
ABSTRACT
Recently, the BM has been shown to play a key role in regulating the survival and function of memory T cells. However, the impact of aging on these processes has not yet been studied. We demonstrate that the number of CD4⺠and CD8⺠T cells in the BM is maintained during aging. However, the composition of the T cell pool in the aged BM is altered with a decline of naïve and an increase in T(EM) cells. In contrast to the PB, a highly activated CD8âºCD28â» T cell population, which lacks the late differentiation marker CD57, accumulates in the BM of elderly persons. IL-6 and IL-15, which are both increased in the aged BM, efficiently induce the activation, proliferation, and differentiation of CD8⺠T cells in vitro, highlighting a role of these cytokines in the age-dependent accumulation of highly activated CD8âºCD28â» T cells in the BM. Yet, these age-related changes do not impair the maintenance of a high number of polyfunctional memory CD4⺠and CD8⺠T cells in the BM of elderly persons. In summary, aging leads to the accumulation of a highly activated CD8âºCD28â» T cell population in the BM, which is driven by the age-related increase of IL-6 and IL-15. Despite these changes, the aged BM is a rich source of polyfunctional memory T cells and may thus represent an important line of defense to fight recurrent infections in old age.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
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Envelhecimento
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Subpopulações de Linfócitos T
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Memória Imunológica
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Leukoc Biol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Áustria