Rapid conversion of spirostans into furostan skeletons at room temperature.
Steroids
; 77(1-2): 59-66, 2012 Jan.
Article
em En
| MEDLINE
| ID: mdl-22061618
ABSTRACT
We report a facile protocol to obtain 22-substituted furostans and pseudosapogenins in high yields from (25R)- and (25S)-sapogenins. This method involves the treatment of the sapogenin with acetic-trifluoroacetic mixed anhydride and BF(3)·OEt(2) at room temperature, followed by the addition of a nucleophile (H(2)O, MeOH or KSeCN). In the case of 22-hydroxyfurostans, they can be transformed to pseudosapogenins by treatment with p-toluensulfonic acid.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sapogeninas
/
Espirostanos
/
Química Farmacêutica
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Guideline
Idioma:
En
Revista:
Steroids
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
México