Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.
Nat Struct Mol Biol
; 18(12): 1432-4, 2011 Nov 13.
Article
em En
| MEDLINE
| ID: mdl-22081012
ABSTRACT
Metabolism is predicted to generate formaldehyde, a toxic, simple, reactive aldehyde that can damage DNA. Here we report a synthetic lethal interaction in avian cells between ADH5, encoding the main formaldehyde-detoxifying enzyme, and the Fanconi anemia (FA) DNA-repair pathway. These results define a fundamental role for the combined action of formaldehyde catabolism and DNA cross-link repair in vertebrate cell survival.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reparo do DNA
/
Anemia de Fanconi
/
Formaldeído
Limite:
Animals
Idioma:
En
Revista:
Nat Struct Mol Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Reino Unido