[Determination of a dimethylaniline mixture in the intermediate products for the production of semisynthetic penicillins]. / Opredelenie primesi dimetilanilina v poluproduktakh dlia proizvodstva polusinteticheskikh penitsillinov.
Antibiotiki
; 24(5): 328-31, 1979 May.
Article
em Ru
| MEDLINE
| ID: mdl-220909
ABSTRACT
A gas-chromatographic method for determination fo the content of dimethylaniline (DMA) in 6-aminopenicillanic acid, a semi-product for production of semi-synthetic antibiotics, was elaborated. The chloroform extracts of DMA from the alkaline solutions of the preparation were analysed in a gas chromatograph with a flame-ionization detector on a stainless steel column 2 m long and the inner diameter of 2 mm filled with 10 per cent OV-17 on chromosorb W-HMDS at a temperature of 112 degrees C. The minimum detectable amount of DMA was 5.10(-9) g. The assay error was +/- 5.35 per cent. The method may be used for the assay of other semi-synthetic antibiotics.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Penicilinas
/
Contaminação de Medicamentos
/
Compostos de Anilina
Idioma:
Ru
Revista:
Antibiotiki
Ano de publicação:
1979
Tipo de documento:
Article