H2S: a universal defense against antibiotics in bacteria.
Science
; 334(6058): 986-90, 2011 Nov 18.
Article
em En
| MEDLINE
| ID: mdl-22096201
ABSTRACT
Many prokaryotic species generate hydrogen sulfide (H(2)S) in their natural environments. However, the biochemistry and physiological role of this gas in nonsulfur bacteria remain largely unknown. Here we demonstrate that inactivation of putative cystathionine ß-synthase, cystathionine γ-lyase, or 3-mercaptopyruvate sulfurtransferase in Bacillus anthracis, Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli suppresses H(2)S production, rendering these pathogens highly sensitive to a multitude of antibiotics. Exogenous H(2)S suppresses this effect. Moreover, in bacteria that normally produce H(2)S and nitric oxide, these two gases act synergistically to sustain growth. The mechanism of gas-mediated antibiotic resistance relies on mitigation of oxidative stress imposed by antibiotics.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Farmacorresistência Bacteriana Múltipla
/
Sulfeto de Hidrogênio
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Antibacterianos
Idioma:
En
Revista:
Science
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos