Simultaneous delivery of tenofovir and acyclovir via an intravaginal ring.
Antimicrob Agents Chemother
; 56(2): 875-82, 2012 Feb.
Article
em En
| MEDLINE
| ID: mdl-22123689
ABSTRACT
Vaginal microbicides may play an important role in protecting women from HIV infection. A strong synergy between HSV and HIV has been observed, and epidemiological studies demonstrate that HSV infection increases the risk of HIV acquisition. Incorporation of the antiretroviral tenofovir (TFV) along with the antiherpetic acyclovir (ACV) into combination intravaginal rings (IVRs) for sustained mucosal delivery of both compounds could lead to increased microbicide product adherence and efficacy compared with conventional vaginal formulations. A novel, dual-protection "pod IVR" platform developed in-house and delivering ACV and TFV was evaluated in rabbit and sheep models. The devices were safe and exhibited sustained release of both drugs independently and at controlled rates over the 28-day studies. Daily release rates were estimated based on residual drug content of the used devices rabbits, 343 ± 335 µg day(-1) (ACV) and 321 ± 207 µg day(-1) (TFV); sheep, 174 ± 14 µg day(-1) (ACV) and 185 ± 34 µg day(-1) (TFV). Mean drug levels in sheep vaginal samples were as follows secretions, 5.25 ± 7.31 µg ml(-1) (ACV) and 20.6 ± 16.2 µg ml(-1) (TFV); cervicovaginal lavage fluid, 118 ± 113 ng ml(-1) (ACV) and 191 ± 125 ng ml(-1) (TFV); tissue, 173 ng g(-1) (ACV) and 93 ng g(-1) (TFV). An in vitro-in vivo correlation was established for both drugs and will allow the development of future formulations delivering target levels for prophylaxis and therapy. These data suggest that the IVR based on the pod design has potential in the prevention of transmission of HIV-1 and other sexually transmitted pathogens.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aciclovir
/
Adenina
/
Herpes Genital
/
Infecções por HIV
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HIV-1
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Herpesvirus Humano 2
/
Organofosfonatos
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos