Synapsin peptide fused to E. coli heat-labile toxin B subunit induces regulatory T cells and modulates cytokine balance in experimental autoimmune encephalomyelitis.
J Neuroimmunol
; 242(1-2): 16-25, 2012 Jan 18.
Article
em En
| MEDLINE
| ID: mdl-22138356
ABSTRACT
We previously found that the preventive oral administration of a hybrid consisting of the C domain of synapsin and the B subunit of E. coli heat-labile enterotoxin (LTBSC) efficiently suppresses experimental autoimmune encephalomyelitis (EAE) development in rats. We investigated the effect of LTBSC on cytokine expression and on regulatory T (Treg) cells in rats with myelin induced EAE. LTBSC treatment increased the frequency of CD4(+)FoxP3(+) Treg cells in lymph nodes prior to challenge and in the EAE acute stage. LTBSC also up-regulated the expression of anti-inflammatory Th2/Th3 cytokines and diminished myelin basic protein-specific Th1 and Th17 cell responses in lymph nodes. CD4(+)CD25(+) Treg cells from LTBSC treated rats showed stronger suppressive properties than Treg cells from controls in vitro. Our observations indicate that LTBSC is a useful agent for modulating the autoimmune responses in EAE.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Toxinas Bacterianas
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Ativação Linfocitária
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Citocinas
/
Sinapsinas
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Linfócitos T Reguladores
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Vacinas contra Escherichia coli
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Proteínas de Escherichia coli
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Encefalomielite Autoimune Experimental
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Enterotoxinas
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Argentina