Modulation of TCRß surface expression during TCR revision.
Cell Immunol
; 272(2): 124-9, 2012.
Article
em En
| MEDLINE
| ID: mdl-22138498
ABSTRACT
TCR revision is a tolerance mechanism by which self-reactive TCRs expressed by mature CD4(+) peripheral T cells are replaced by receptors encoded by genes generated by post-thymic DNA rearrangement. The downmodulation of surface TCR expression initiates TCR revision, and serves as a likely trigger for the induction of the recombinase machinery. We show here in a Vß5 transgenic mouse model system that downregulation of the self-reactive transgene-encoded TCR is not maintained by transgene loss or diminished transcription or translation. The downregulation of surface TCR expression likely occurs in two stages, only one of which requires tolerogen expression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T alfa-beta
/
Rearranjo Gênico da Cadeia beta dos Receptores de Antígenos dos Linfócitos T
Limite:
Animals
Idioma:
En
Revista:
Cell Immunol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos