The association of antiphospholipid antibodies with intrauterine fetal death: a case-control study.
Thromb Res
; 130(1): 32-7, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22178574
ABSTRACT
INTRODUCTION:
Over the past few decades it has been recognized that antiphospholipid antibodies are associated with pregnancy loss. Other placenta-mediated pregnancy complications have also been associated with the presence of antiphospholipid antibodies. Most studies have measured antiphospholipid antibodies near the time of the event investigated.OBJECTIVES:
To investigate the association of antiphospholipid antibodies and a history of intrauterine fetal death (IUFD) in a case-control design. MATERIALS ANDMETHODS:
A case-control study of 105 women with a history of IUFD after 22 gestational weeks and 262 controls with live births. The prevalence of lupus anticoagulant, anticardiolipin- and anti-ß2-glycoprotein 1 antibodies were measured 3-18years after the event of IUFD.RESULTS:
Total 9.5% of women with a history of IUFD and 5.0% of controls had at least one positive test for antiphospholipid antibodies (OR 2.0; 95% confidence interval (CI) 0.9-4.8). Women with a history of IUFD were significantly more often positive for lupus anticoagulant compared to controls (OR 4.3; 95% CI 1.0-18.4). The association of lupus anticoagulant with a history of IUFD was confined to women positive for other antiphospholipid antibodies in addition to lupus anticoagulant. Being positive for anti-ß2-glycoprotein 1 or anticardiolipin antibodies alone was not significantly associated with a history of IUFD.CONCLUSIONS:
Women with a history of IUFD after 22 gestational weeks were more often lupus anticoagulant positive. The association was confined to women with multiple positivity for antiphospholipid antibodies, although firm conclusions on the importance of multiple positivity cannot be made from this study.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Antifosfolipídeos
/
Morte Fetal
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
/
Humans
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Pregnancy
Idioma:
En
Revista:
Thromb Res
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Noruega