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KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion.
Porzionato, A; Fenu, G; Rucinski, M; Macchi, V; Montella, A; Malendowicz, L K; De Caro, R.
Afiliação
  • Porzionato A; Section of Anatomy, Department of Human Anatomy and Physiology, University of Padova, Italy.
Eur J Histochem ; 55(2): e14, 2011 May 04.
Article em En | MEDLINE | ID: mdl-22193294
KISS1 and its receptor, KISS1R, have both been found to be expressed in central nervous system, but few data are present in the literature about their distribution in peripheral nervous structures. Thus, the aim of the present study was to investigate, through immunohistochemistry, the expression and distribution of KISS1 and KISS1R in the rat and human carotid bodies and superior cervical ganglia, also with particular reference to the different cellular populations. Materials consisted of carotid bodies and superior cervical ganglia were obtained at autopsy from 10 adult subjects and sampled from 10 adult Sprague-Dawley rats. Immunohistochemistry revealed diffuse expression of KISS1 and KISS1R in type I cells of both human and rat carotid bodies, whereas type II cells were negative. In both human and rat superior cervical ganglia positive anti-KISS1 and -KISS1R immunostainings were also selectively found in ganglion cells, satellite cells being negative. Endothelial cells also showed moderate immunostaining for both KISS1 and KISS1R. The expression of both kisspeptins and kisspeptin receptors in glomic type I cells and sympathetic ganglion cells supports a modulatory role of KISS1 on peripheral chemoreception and sympathetic function. Moreover, local changes in blood flow have been considered to be involved in carotid body chemoreceptor discharge and kisspeptins and kisspeptin receptors have also been found in the endothelial cells. As a consequence, a possible role of kisspeptins in the regulation of carotid body blood flow and, indirectly, in chemoreceptor discharge may also be hypothesized.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Corpo Carotídeo / Regulação da Expressão Gênica / Gânglio Cervical Superior / Receptores Acoplados a Proteínas G / Kisspeptinas Limite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Histochem Assunto da revista: HISTOCITOQUIMICA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Itália País de publicação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Corpo Carotídeo / Regulação da Expressão Gênica / Gânglio Cervical Superior / Receptores Acoplados a Proteínas G / Kisspeptinas Limite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Histochem Assunto da revista: HISTOCITOQUIMICA Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Itália País de publicação: Itália