Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels.
J Neurophysiol
; 107(6): 1571-5, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22205650
ABSTRACT
Ifenprodil is a selective blocker of NMDA receptors that are heterodimers composed of GluN1/GluN2B subunits. This pharmacological profile has been extensively used to test the role of GluN2B-containing NMDA receptors in learning and memory formation. However, ifenprodil has also been reported to have actions at a number of other receptors, including high voltage-activated calcium channels. Here we show that, in the basolateral amygdala, ifenprodil dose dependently blocks excitatory transmission to principal neurons by a presynaptic mechanism. This action of ifenprodil has an IC(50) of ~10 µM and is fully occluded by the P/Q type calcium channel blocker ω-agatoxin. We conclude that ifenprodil reduces synaptic transmission in the basolateral amygdala by partially blocking P-type voltage-dependent calcium channels.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Bloqueadores dos Canais de Cálcio
/
Potenciais Pós-Sinápticos Excitadores
/
Canais de Cálcio Tipo P
/
Canais de Cálcio Tipo Q
/
Tonsila do Cerebelo
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
J Neurophysiol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Austrália