Caffeine effects on resting-state electrodermal levels in AD/HD suggest an anomalous arousal mechanism.
Biol Psychol
; 89(3): 606-8, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-22266163
ABSTRACT
The effect of a single oral dose of caffeine was examined in a randomised double-blind placebo-controlled repeated-measures cross-over study. Eighteen children with AD/HD, aged between 8 and 13 years, were individually age- and gender-matched with a control group. All children participated in two sessions, one week apart. Skin conductance level (SCL) from a 3 min eyes-closed epoch, commencing 30 min after ingestion of caffeine or placebo, was examined. Across conditions, mean SCL was lower in the AD/HD group than controls, confirming hypoarousal in AD/HD. Caffeine produced an increase in SCL, and this increase did not differ between the groups. However, arousal increases were dose-dependent in controls, but not in AD/HD. Rather, caffeine-induced arousal increases in the AD/HD group were positively related to their hyperactivity/impulsivity levels. This suggests an anomalous arousal mechanism in AD/HD functionally related to impairment in one symptom dimension.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Descanso
/
Transtorno do Deficit de Atenção com Hiperatividade
/
Cafeína
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Resposta Galvânica da Pele
/
Estimulantes do Sistema Nervoso Central
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Biol Psychol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Austrália