Antitumor cyclic hexapeptides from rubia plants: history, chemistry, and mechanism (2005-2011).

ABSTRACT

Rubiaceae-type cyclopeptides (RAs), cyclic hexapeptides from Rubia plants, have shown potential antitumor activity in vitro and in vivo. Based on the review about plant cyclopeptides (Chem. Rev., 2006, 106 840), this mini-review will highlight new progress on the discovery, synthesis, and mechanism of RAs isolated during 2005 to 2011, covering recent work in our group.