Infiltration of melanoma cells into the type I collagen gel.
J Dermatol
; 17(8): 473-6, 1990 Aug.
Article
em En
| MEDLINE
| ID: mdl-2229650
ABSTRACT
Melanoma cells were cultured on type I collagen gel, and the infiltration of of those cells into the gel was observed. B16 murine melanoma cells initially adopted a spherical form on the gel, but they assumed a dendritic form after infiltration into the interior. The degree of infiltration increased very rapidly and was time-dependent. No correlations between the growth rate or melanogenic activity and infiltrative potential were observed. When Syrian hamster and human melanoma cell lines were cultured, the degrees of infiltration varied. This culture system using collagen gel is considered to be a useful in vitro model of tumor cell invasion.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Melanoma Experimental
/
Colágeno
Limite:
Animals
Idioma:
En
Revista:
J Dermatol
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Japão