Distribution, kinetics and immunoscintigraphy of 131-I labelled intact antifibrinogen-fibrin antibody (AbFbg) and its F(ab')2 fragment.
Int J Biol Markers
; 5(1): 1-6, 1990.
Article
em En
| MEDLINE
| ID: mdl-2230346
ABSTRACT
131-I-labelled anti fibrin-fibrinogen antibody (AbFbg) was compared with its F(ab')2 fragment in distribution studies and by immunoscintigraphy with a view to tumour visualization in tumour bearing rats. The distribution studies indicated that the intact antibody is more concentrated in tumour tissue than the F(ab')2 fragment. By 168h after injection, when tumour-to-tissue ratios were highest in the majority of tissues, the tumour concentration of intact antibody was 3 to 4 times that of the F(ab')2 fragment. The intact antibody is more suitable than the F(ab')2 fragment for tumour imaging especially in the abdominal region where the highest tumour-to tissue ratios were obtained with intact antibody in liver, spleen, intestines and kidneys.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoma de Yoshida
/
Fibrinogênio
/
Imunoglobulinas
/
Fragmentos Fab das Imunoglobulinas
/
Fibrina
/
Fragmentos de Imunoglobulinas
Limite:
Animals
Idioma:
En
Revista:
Int J Biol Markers
Assunto da revista:
BIOQUIMICA
/
NEOPLASIAS
Ano de publicação:
1990
Tipo de documento:
Article