High frequency of false positive IgM immunoblots for Borrelia burgdorferi in clinical practice.
Clin Microbiol Infect
; 18(12): 1236-40, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22369185
Although it is known that two-tier serologic testing for Lyme disease may be associated with false positive results on the IgM immunoblot, this problem has never been systematically studied in the clinical practice setting. In a retrospective investigation of patients referred to the private adult practice of an Infectious Diseases physician for possible for Lyme disease, 50 of 182 patients (27.5%, 95% CI: 21.1-34.6) were found to have a false positive IgM immunoblot. 78.0% of these patients had received unnecessary antibiotic therapy. False positive results were not restricted to any single commercial laboratory. Research on alternative testing strategies that eliminate the IgM immunoblot entirely is warranted.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina M
/
Doença de Lyme
/
Immunoblotting
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Técnicas de Laboratório Clínico
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Borrelia burgdorferi
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Reações Falso-Positivas
/
Anticorpos Antibacterianos
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
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Aged
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Female
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Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Microbiol Infect
Assunto da revista:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Reino Unido