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Nonplasmacytoid, high IFN-α-producing, bone marrow dendritic cells.
O'Keeffe, Meredith; Fancke, Ben; Suter, Mark; Ramm, Georg; Clark, Joan; Wu, Li; Hochrein, Hubertus.
Afiliação
  • O'Keeffe M; Centre for Immunology, Burnet Institute, Melbourne, Victoria 3004, Australia. meredith@burnet.edu.au
J Immunol ; 188(8): 3774-83, 2012 Apr 15.
Article em En | MEDLINE | ID: mdl-22422879
Plasmacytoid dendritic cells (pDC) are the producers of type I IFNs in response to TLR9 ligands. However, we have found that when bone marrow is depleted of pDC, the IFN-α produced in response to TLR9 ligands is not fully removed. We assign the source of this non-pDC IFN-α as a newly described DC type. It displays the high IFN-α producing activity of pDC but to a more limited range of viruses. Unlike pDC, the novel DC display high T cell stimulation capacity. Moreover, unlike mouse pDC, they are matured with GM-CSF and are less prone to apoptosis upon activation stimuli, including viruses. We propose that these DC constitute a novel bone marrow inflammatory DC type, ideally geared to linking innate and adaptive immune responses in bone marrow via their potent IFN-α production and high T cell stimulatory capacity.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Dendríticas / Células da Medula Óssea / Linfócitos T / Interferon-alfa Limite: Animals / Female / Humans / Male Idioma: En Revista: J Immunol Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Austrália País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Dendríticas / Células da Medula Óssea / Linfócitos T / Interferon-alfa Limite: Animals / Female / Humans / Male Idioma: En Revista: J Immunol Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Austrália País de publicação: Estados Unidos