Oral bone loss induced by mineral deficiency in a rat model: effect of a synthetic bone mineral (SBM) preparation.
Arch Oral Biol
; 57(9): 1264-73, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22424637
ABSTRACT
UNLABELLED Osteoporosis affects the craniofacial and oral structures and has been associated with periodontal bone loss, tooth loss and reduced jaw bone mass. OBJECTIVE:
This study aimed to test the therapeutic efficacy of synthetic bone mineral (SBM) in minimizing alveolar bone loss induced by mineral deficiency in a rat model. SBM consists of a calcium carbonate apatite (similar to bone apatite) matrix incorporating magnesium, zinc, and fluoride ions.DESIGN:
Thirty female Sprague Dawley rats (2 months old) were randomly distributed into 3 groups (10 rats per group) GA (control), on basic diet; GB, on mineral deficient (MD) diet; and GC, on MD+SBM. The rats were sacrificed after 3 months, the jawbones were isolated and the soft tissues removed. Bone density was determined using X-ray radiography (Faxitron); mandibular cortical width, panoramic mandibular index, and alveolar resorption degree (M/M ratio) using BioquantOsteo; and bone micro-architecture micro-computed tomography and scanning electron microscopy.RESULTS:
Compared to control (GA), the rats on MD diet (GB) experienced significant mandibular bone loss while the rats on MD+SBM diet (GC) experienced significantly less bone loss compared to the GB group.CONCLUSION:
SBM, administered orally, may have the potential as an osteoporosis therapeutic agent in minimizing or preventing alveolar bone loss induced by mineral deficiency.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apatitas
/
Carbonato de Cálcio
/
Perda do Osso Alveolar
/
Deficiências Nutricionais
/
Conservadores da Densidade Óssea
/
Minerais
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Arch Oral Biol
Ano de publicação:
2012
Tipo de documento:
Article