CCL5, CCR1 and CCR5 in murine glioblastoma: immune cell infiltration and survival rates are not dependent on individual expression of either CCR1 or CCR5.
J Neuroimmunol
; 246(1-2): 10-7, 2012 May 15.
Article
em En
| MEDLINE
| ID: mdl-22425022
ABSTRACT
Glioblastoma multiforme (GBM) is the most malignant brain tumor. Microglia/macrophages are found within human GBM where they likely promote tumor progression. We report that CCL5, CCR1, and CCR5 are expressed in glioblastoma. Individual deletion of CCR1 or CCR5 had little to no effect on survival of tumor bearing mice, or numbers of glioblastoma-infiltrated microglia/macrophages or lymphocytes. CCL5 promoted in vitro migration of wild type, CCR1- or CCR5-deficient microglia/macrophages that was blocked by the dual CCR1/CCR5 antagonist, Met-CCL5. These data suggest that CCL5 functions within the glioblastoma microenvironment through CCR1 and CCR5 in a redundant manner.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Movimento Celular
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Regulação da Expressão Gênica
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Glioblastoma
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Quimiocina CCL5
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Receptores CCR5
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Receptores CCR1
Limite:
Animals
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Humans
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos