Cluster analysis of autistic patients based on principal pathogenetic components.
Autism Res
; 5(2): 137-47, 2012 Apr.
Article
em En
| MEDLINE
| ID: mdl-22431251
ABSTRACT
We have recently described four principal pathogenetic components in autism (I) circadian and sensory dysfunction, (II) immune abnormalities, (III) neurodevelopmental delay, and (IV) stereotypic behaviors. Using hierarchical and k-means clustering, the same 245 patients assessed in our principal component analysis can be partitioned into four clusters (a) 43 (17.6%) have prominent immune abnormalities accompanied by some circadian and sensory issues; (b) 44 (18.0%) display major circadian and sensory dysfunction, with little or no immune symptoms; (c) stereotypies predominate in 75 (31.0%); and (d) 83 (33.9%) show a mixture of all four components, with greater disruptive behaviors and mental retardation. The "immune" component provides the largest contributions to phenotypic variance (P = 2.7 x 10(-45)), followed by "stereotypic behaviors." These patient clusters may likely differ in genetic and immune underpinnings, developmental trajectories, and response to treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Globais do Desenvolvimento Infantil
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Autism Res
Assunto da revista:
PSIQUIATRIA
/
TRANSTORNOS MENTAIS
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália