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Early improvement in carotid plaque echogenicity by acarbose in patients with acute coronary syndromes.
Hirano, Mitsumasa; Nakamura, Takamitsu; Obata, Jyun-ei; Fujioka, Daisuke; Saito, Yukio; Kawabata, Ken-ichi; Watanabe, Kazuhiro; Watanabe, Yosuke; Kugiyama, Kiyotaka.
Afiliação
  • Hirano M; Department of Internal Medicine II, University of Yamanashi, Faculty of Medicine, Chuo, Japan.
Circ J ; 76(6): 1452-60, 2012.
Article em En | MEDLINE | ID: mdl-22453003
BACKGROUND: The resolution of hyperglycemia is associated with suppression of in-hospital cardiac complications in patients with acute coronary syndromes (ACS). This study evaluated carotid artery plaque echolucency using ultrasound in patients with ACS and type 2 diabetes mellitus (DM) to determine whether acarbose, an α-glucosidase inhibitor, may rapidly stabilize unstable atherosclerotic plaques. METHODS AND RESULTS: ACS patients with type 2 DM and carotid plaques (n=44) were randomly assigned to treatment with acarbose (150 or 300 mg/day, n=22) or a control group (no acarbose, n=22). Acarbose treatment was initiated within 5 days after the onset of ACS. Unstable carotid plaques were assessed by measuring plaque echolucency using carotid ultrasound with integrated backscatter (IBS) before, and at 2 weeks, 1 and 6 months after the initiation of treatment. An increase in the IBS value reflected an increase in carotid plaque echogenicity. As results, the IBS value of echolucent carotid plaques showed a significant increase at 1 month and a further increase at 6 months after treatment in the acarbose group, but there was minimal change in the control group. The increase in IBS values was significantly correlated with a decrease in C-reactive protein levels. CONCLUSIONS: Acarbose rapidly improved carotid plaque echolucency within 1 month of therapy in patients with ACS and type 2 DM.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artérias Carótidas / Doenças das Artérias Carótidas / Acarbose / Diabetes Mellitus Tipo 2 / Inibidores Enzimáticos / Síndrome Coronariana Aguda / Inibidores de Glicosídeo Hidrolases / Hipoglicemiantes Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Circ J Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Japão País de publicação: Japão
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artérias Carótidas / Doenças das Artérias Carótidas / Acarbose / Diabetes Mellitus Tipo 2 / Inibidores Enzimáticos / Síndrome Coronariana Aguda / Inibidores de Glicosídeo Hidrolases / Hipoglicemiantes Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Revista: Circ J Assunto da revista: ANGIOLOGIA / CARDIOLOGIA Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Japão País de publicação: Japão