Terguride in the treatment of Parkinson disease: preliminary experience.
Ital J Neurol Sci
; 11(4): 381-5, 1990 Aug.
Article
em En
| MEDLINE
| ID: mdl-2246121
ABSTRACT
Terguride, a partial DA-agonist with both dopaminergic and antidopaminergic properties, was tested in 11 PD patients in the "decompensated" phase of the disease, characterized by the presence of dyskinesias and motor fluctuations. Combined treatment of these patients with 1 mg/day of terguride and stabilized doses of levodopa reduced the severity and frequency of dyskinesias and motor fluctuations along with a slight but significant improvement of parkinsonian clinical picture. The "modulatory" effect of terguride on DA receptors, in this experimental conditions, is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Lisurida
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ital J Neurol Sci
Ano de publicação:
1990
Tipo de documento:
Article