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[Good's syndrome (thymoma associated hypogammalobulinaemia) - 2 case reports]. / Gooduv syndrom (s thymomem spojená hypogamaglobulinemie) - 2 kazuistiky.
Králícková, P; Slezák, R; Vosmik, M; Malá, P; Hornychová, H; Brozík, J; Melichar, B.
Afiliação
  • Králícková P; Ústac Klinické Imunologie a Alergologie Lékarské Fakulty UK a FN Hrade Králové, Prednosta prof. RNDr. Jan Krejsek, CSc. kralickova.pavlina@fnhk.cz
Vnitr Lek ; 58(2): 154-61, 2012 Feb.
Article em Cs | MEDLINE | ID: mdl-22463097
ABSTRACT
Although tumours of the thymus are rare, they are common among neoplasms of the anterior superior mediastinum. They usually exhibit indolent behavior, but do have the capacity to invade surrouding structures. Their metastatic potential is low. Paraneoplastic complications including autoimmune disorders (frequently myastenia, cytopenia) or combined immunodeficiency are of clinical significance. Here we report two case reports of thymoma patients associated with secondary immunodeficiency known as Goods syndrom. The first case exhibited as symptomatic combinated immunodeficiency with oral lichen planus. Thymoma findings was accidental. Severity of immunodeficiency required long-term intravenous immunoglobulins supplementations, even after complete surgical resection. On the other hand, the second case manifested by signs of advanced local tumour growth. Antibiotic prophylaxis was selected as immunodeficiency treatment.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Timoma / Neoplasias do Timo / Agamaglobulinemia Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Middle aged Idioma: Cs Revista: Vnitr Lek Ano de publicação: 2012 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Timoma / Neoplasias do Timo / Agamaglobulinemia Tipo de estudo: Diagnostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Middle aged Idioma: Cs Revista: Vnitr Lek Ano de publicação: 2012 Tipo de documento: Article