Cardiovascular baroreceptor activity and selective inhibition of monoamine oxidase.
Eur J Pharmacol
; 683(1-3): 226-30, 2012 May 15.
Article
em En
| MEDLINE
| ID: mdl-22465184
Cardiovascular baroreceptor responsiveness of conscious rats treated with selective inhibitors of monoamine oxidase (MAO) types A and B was determined by measurement of blood pressure (BP) and heart rate (HR) responses to intravenous injection of phenylephrine and sodium nitroprusside. Treatment with selegiline (1 or 5 mg/kg p.o. daily for 7 days) did not significantly modify resting levels of BP and HR, lower or upper HR plateau levels, or HR/BP gain. Treatment with clorgyline (2 mg/kg p.o. daily for 7 days) increased HR/BP gain but also did not modify resting BP or HR, or lower and upper plateau levels of HR. The results are compatible with an effect of MAO-A inhibition to modify monoamine levels in medullary areas participating in CNS control of blood pressure.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressorreceptores
/
Sistema Cardiovascular
/
Barorreflexo
/
Monoaminoxidase
/
Inibidores da Monoaminoxidase
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Israel
País de publicação:
Holanda