Investigation of the effects of head irradiation with gamma rays and protons on startle and pre-pulse inhibition behavior in mice.
Radiat Res
; 177(5): 685-92, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22468701
ABSTRACT
With the increased international emphasis on manned space exploration, there is a growing need to understand the impact of the spaceflight environment on health and behavior. One particularly important aspect of this environment is low-dose radiation. In the present studies, we first characterized the γ- and proton-irradiation dose effect on acoustic startle and pre-pulse inhibition behaviors in mice exposed to 0-5 Gy brain-localized irradiation, and assessed these effects 2 days later. Subsequently, we used 2 Gy to assess the time course of γ- and proton-radiation effects on startle reactivity 0-8 days after exposure. Exposures targeted the brain to minimize the impact of peripheral inflammation-induced sickness behavior. The effects of radiation on startle were subtle and acute. Radiation reduced the startle response at 2 and 5 Gy. Following a 2-Gy exposure, the response reached a minimum at the 2-day point. Proton and γ-ray exposures did not differ in their impact on startle. We found there were no effects of radiation on pre-pulse inhibition of the startle response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prótons
/
Reflexo de Sobressalto
/
Irradiação Craniana
/
Filtro Sensorial
/
Raios gama
Limite:
Animals
Idioma:
En
Revista:
Radiat Res
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Estados Unidos