Why are upper motor neuron signs difficult to elicit in amyotrophic lateral sclerosis?
J Neurol Neurosurg Psychiatry
; 83(6): 659-62, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22496581
ABSTRACT
It is often difficult to identify signs of upper motor neuron lesion in the limbs of patients with amyotrophic lateral sclerosis, in whom there is neurogenic muscle wasting of varying severity. The reasons for this are complex and not related simply to the degree of lower motor neuron muscle wasting but, rather, depend on the pathophysiological abnormalities that develop in response to damage to descending motor pathways and to motor neurons and interneurons in the ventral horns of the spinal cord. The different mechanisms underlying the clinical phenomenology of the functional motor defect in amyotrophic lateral sclerosis, that lead to difficulty in detecting classical upper motor neuron signs, are discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Esclerose Lateral Amiotrófica
/
Neurônios Motores gama
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Qualitative_research
Limite:
Humans
Idioma:
En
Revista:
J Neurol Neurosurg Psychiatry
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Reino Unido