[Genetic variants of haptoglobin in patients with destructive pulmonary tuberculosis]. / Geneticheskie varianty gaptoglobina u bol'nykh destruktivnym tuberkulezom legkikh.

ABSTRACT

Haptoglobin (Hb) phenotyping was carried out in 143 patients with tuberculosis and 221 practically healthy persons. Three phenotypes were distinguished two homozygotic Hp. 11 and Hp. 22 and one heterozygotic Hp. 21. An analysis of the frequency of distribution of the above-mentioned phenotypes indicates that patients with tuberculosis as compared with the healthy showed a significant reduction of the number of Hp. 21 carriers while the number of Hp. 22 increased. There was a definite dependence between the haptoglobin phenotype and course of the disease. In carriers of the Hp. 21 abacillation of the sputum and closure of destructions occurred earlier than in carriers of Hp 11 and, in particular, Hp. 22.