A comparative study of xylazine-induced mechanical hypoalgesia in donkeys and horses.
Vet Anaesth Analg
; 39(5): 533-8, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22574779
ABSTRACT
OBJECTIVE:
To compare the effects of xylazine on mechanical nociceptive thresholds in donkeys and horses. STUDYDESIGN:
Randomized, controlled, crossover, Latin-square, operator-blinded design. ANIMALS Six 3.1 ± 0.89 year old standard donkeys weighing 145.0 ± 30.5 kg and six 9.6 ± 4.4 year old Thoroughbred horses weighing 456.0 ± 69.0 kg.METHODS:
Each animal received one of four doses of xylazine (0.5, 0.7, 0.9, and 1.1 mg kg(-1) ), or acepromazine (0.05 mg kg(-1) ) or saline solution (0.9%) intravenously and mechanical nociceptive thresholds were assessed over 90 minutes. The areas under the threshold change versus time curve values for 60 minutes (AUC(0-60) ) post-drug administration were used to compare the effect of treatment. A 1-week interval was allowed between successive trials on each animal.RESULTS:
All doses of xylazine, but not acepromazine or saline, increased mechanical thresholds for up to 60 minutes. Xylazine-induced hypoalgesia was dose-dependent and corresponding AUC(0-60) values for each treatment were not significantly different between donkeys and horses (p ≥ 0.0697).CONCLUSION:
The hypoalgesic effects of xylazine at four different doses were not different between donkeys and horses. CLINICAL RELEVANCE Xylazine induced a similar degree of mechanical hypoalgesia in donkeys and horses suggesting that similar doses are needed for both species with regard to analgesia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Xilazina
/
Equidae
/
Analgésicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Vet Anaesth Analg
Assunto da revista:
ANESTESIOLOGIA
/
MEDICINA VETERINARIA
Ano de publicação:
2012
Tipo de documento:
Article