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Curcumin protects against cigarette smoke-induced cognitive impairment and increased acetylcholinesterase activity in rats.
Jaques, Jeandre Augusto dos Santos; Rezer, João Felipe Peres; Carvalho, Fabiano Barbosa; da Rosa, Michelle Melgarejo; Gutierres, Jessié Martins; Gonçalves, Jamile Fabbrin; Schmatz, Roberta; de Bairros, André Valle; Mazzanti, Cinthia Melazzo; Rubin, Maribel Antonello; Schetinger, Maria Rosa Chitolina; Leal, Daniela Bitencourt Rosa.
Afiliação
  • Jaques JA; Centro de Ciências Naturais e Exatas, Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Laboratório de Enzimologia Toxicológica, Universidade Federal de Santa Maria, Campus Universitário, Camobi, Prédio 18, Sala 2208, 97105-900, Santa Maria, RS, Brazil.
Physiol Behav ; 106(5): 664-9, 2012 Jul 16.
Article em En | MEDLINE | ID: mdl-22579739
Cigarette smoke, a widely spread habit, is associated with a decline in cognitive function and studies have demonstrated that curcumin (Cur), an Indian spice, possesses a strong neuroprotective potential. Considering the relevance of investigating dietary compounds this study aimed to investigate the effect of Cur on memory and acetylcholinesterase (AChE) activity in brain structures and blood of cigarette smoke-exposed rats. Male Wistar rats were treated with curcumin and cigarette smoke, once a day, 5 days each week, for 30 days. The experimental procedures were divided in two sets of experiments. In the first, the animals were divided into 4 groups: Vehicle (corn oil), Cur 12.5 mg/kg, Cur 25 mg/kg and Cur 50 mg/kg. In the second, the animals were divided into 5 groups: Vehicle (corn oil), Smoke, Smoke plus Cur 12.5 mg/kg, Smoke plus Cur 25 mg/kg and Smoke plus Cur 50 mg/kg. Treatment with Cur significantly prevented the decreased latency and cholinergic alterations in cigarette smoke-exposed rats. These AChE alterations could suggest a role in the memory impairment promoted by cigarette smoke-exposure and point toward the potential of Cur to modulate cholinergic neurotransmission and, consequently, improve cognition deficits induced by smoke. This study suggests that the dietary compound Cur may be involved in cholinergic system modulation and as a consequence exert an effect on learning and memory.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Poluição por Fumaça de Tabaco / Anti-Inflamatórios não Esteroides / Transtornos Cognitivos / Curcumina Limite: Animals Idioma: En Revista: Physiol Behav Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcolinesterase / Poluição por Fumaça de Tabaco / Anti-Inflamatórios não Esteroides / Transtornos Cognitivos / Curcumina Limite: Animals Idioma: En Revista: Physiol Behav Ano de publicação: 2012 Tipo de documento: Article País de afiliação: Brasil País de publicação: Estados Unidos